PHRI Peer Review Articles 2003

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Devereaux PJ, McKee MD, Yusuf S. Methodological issues in randomized controlled trials of surgical interventions. Clin Orthop and Related Res. 2003; 413: 25-32.

Sleight P, Yusuf S. New evidence on the importance of the renin-angiotensin system in the treatment of higher-risk patients with hypertension. J Hypertension, 2003; 21(9): 1599-1608.  

Mann JF, Yi QL, Sleight P, Dagenais GR, Probstfield J, Gerstein HC, Lonn EM, Bosch J, Yusuf S; HOPE investigators. New trial data on prevention. Potassium and CV risk in HOPE. Pacing Clin Electrophysiol. 2003 Jul;26(7 Pt 1):1565.  

Devereaux PJ,Yusuf S. The evolution of the randomized controlled trial and its role in evidence-based decision making. J of Internal Medicine. 2003; 254(2):105-13.  

Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, Ostergren J, Yusuf S for the CHARM Investigators and Committees. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall Programme. Lancet 2003; 362: 759-66.  

McMurray JJV, Ostergren J, Swedberg K, Granger CB, Held P, Michelson EL, Olofsson B, Yusuf S, Pfeffer MA for the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function treated with an ACE-inhibitor: the CHARM-Added trial. Lancet 2003; 362: 767-71.  

Granger CB, McMurray JJV, Yusuf S, Held P, Michelson EL, Olofsson B, Ostergren J, Pfeffer MA, Swedberg K, for the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left ventricular systolic function and intolerant to ACE inhibitors: the CHARM-Alternative Trial. Lancet 2003; 362: 772-76.  

Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, and Ostergren J for the CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left ventricular systolic function: the CHARM-Preserved trial. Lancet 2003; 362: 777-81.  

Kelemen LE, Anand SS, Vuksan V, Yi Q, Teo KK, Devanesen S, Yusuf S for the SHARE Investigators. Development and evaluation of cultural food frequency questionnaires for South Asians, Chinese, and Europeans in North America. J AmDiet Assoc 2003; 103: 1178-84.  

Peters RJ, Mehta SR, Fox KA, Zhao F, Lewis BS, Kopecky SL, Diaz R, Commerford PJ, Valentin V, Yusuf S. Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Investigators. Circulation 2003; 108(14): 1682-7.  

Mann JF, Gerstein HC, Yi QL, Franke G, Lonn EM, Hoogwerf BJ, Rashkow A, Yusuf S. Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: Results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized study. Am J Kidney Dis 2003; 42(5): 936-42.  

McKelvie RS, Afzal R, Held P, Maggioni AP, Rouleau JL, White M, Young JB, Yusuf S. Comparative impact of enalapril, candesartan or metoprolol alone or in combination with congestive heart failure. Eur Heart J 2003; 24(19): 1727-34.  

Dagenais GR, Auger P, Bogaty P, Gerstein HC, Lonn E, Yi Q, Yusuf S. Increased occurrence of diabetes in persons with ischemic cardiovascular disease and general and abdominal obesity. Can J Card 2003; 19(12): 1387-91.  

Rihal CS, Raco DR, Gersh BJ, Yusuf S. Indications for coronary artery bypass surgery and percutaneous coronary intervention in chronic unstable angina: review of the evidence and methodological considerations. Circulation 2003; 108: 2439-2445  

Effects of different blood pressure lowering regimens on major cardiovascular events: second cycle of prospectively designed overviews from the Blood Pressure Lowering Treatment Trialists’ Collaboration. The Lancet 2003; 362: 1527-35.  

Collins JF, Egan D, Yusuf S, Garg R, Williford W, Geller N on behalf of the DIG Investigators. Overview of the DIG trial. Cont ClinTrials 2003; 24: 269S-276S.  

Williford W, Collins J, Horney A, Kirk G, McSherry F, Spence E, Stinnett S, Howell C, Garg R, Egan D, Yusuf Sfor the DIG Investigators. The role of the data coordinating center in the DIG trial. Cont Clin Trials 2003; 24: 277S-288S.  

Fye CL, Gagne WH, Raisch DW, Jones MS, Sather MR, Buchanan SL, Chacon FR, Garg R, Yusuf S, Williford WO on behalf of the DIG Investigators.. The role of the pharmacy coordinating center in the DIG trial. Cont Clin Trials 2003; 24: 289S-297S.  

Egan D, Geller N, Yusuf S, Garg R, Collins JF, Mathew J, Philbin E for the DIG investigators. Lessons learned from the Digitalis Investigations Group (DIG) Trial. Cont Clin Trials 2003; 24: 316S-326S.  

Lonn E, Mathew J, Pogue J, Johnstone D, Danisa K, Bosch J, Baird MD M, G, Sleight P, Yusuf S; On behalf of the Heart Outcomes Prevention Evaluation (HOPE) Study investigators. Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients. J Cardio Risk 2003; 10(6): 420-8.

Hackam DG, Anand SS, Yusuf S. Oral anticoagulant therapy in patients with coronary artery disease. Semin Vasc Med 2003; 3(3): 323-32.  

Guzman JC, Leon H, Casas JP, Garcia RG, Silva FA, Bermudez JJ, Lopez-Jaramillo P, Morillo CA. Disfuncion autonomica y vascular en la fase asintomatica de la enfermedad de Chagas. Rev Col Cardiol 2003;11:2003.

Morillo CA. Estudios de prevencion primaria y secundaria de muerte subita en infarto agudo del miocardio (Primary and secondary prevention of sudden cardiac death post myocardial infarction: A Systematic Review of Clinical Trials) Rev Col Cardiol 2003;10: S25-27.  

Grubb B, Vesga BE, Guzman JC, Silva FA, Morillo CA. Sindromes de disfuncion autonomica asociados con intolerancia ortostatica (Syndromes of Autonomic Dysfunction associated with orthostatic intolerance) Biomedica 2003;23:103-114.

Casas JP, Cubillos-Garzon LA, Morillo CA. Regional pathologies and globalization of clinical trials: Has the time for regional trials arrived? Circulation 2003;107:e194.  

Connolly SJ, Sheldon R, Thorpe KE, Roberts RS, Ellenbogen K, Wilkoff BL, Morillo CA, Gent M, on behalf of the VPS II investigators. The second vasovagal pacemaker study (VPS II): A randomized double-blind randomized controlled trial of pacemaker therapy for the prevention of syncope in patients with vasovagal syncope. JAMA 2003;289: 2224-2229.  

Cubillos LA, Casas JP, Morillo CA. Sildenafil in secondary pulmonary hypertension. Int J Cardiol 2003; vol 89:101 - 102 .

Pérez M, Casas JP, Cubillos LA, Serrano NC, Silva FA, Morillo CA, López-Jaramillo PJ. Utility of the Waist Circumference as a Screening Tool to Identify Andean Subjects at Cardiovascular Risk . J Cardiovasc Risk 2003; 10:328-335.  

Crystal E, Kahn S, Roberts R, Thorpe K, Gent M, Cairns JA, Dorian P, Connolly SJ. Long-term amiodarone therapy and the risk of complications after cardiac surgery: Results from the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT). J Thorac Cardiovasc Surg. 2003 Mar;125(3 Pt 1):633-637.  

Connolly SJ, Cybulsky I, Lamy A, Roberts RS, O’Brien B, Carroll S, Crystal E, Thorpe KE, Gent M. A double-blind placebo controlled randomized trial of prophylactic metoprolol for reduction of hospital stay following heart surgery: The beta blocker length of stay (BLOS) study. Am Heart J . 2003 Feb;145(2):226-32  

PageRL, Tilsh TW, Connolly SJ, Schnell DJ, Marcello SR, Wilkinson WE, Pritchett ELC. Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilide. Circulation. 2003 Mar 4;107(8):1141-5.  

Crystal E, Lamy A, Connolly SJ, Kleine P, Hohnloser SH, Semelhago L, Abouzhar L, Cybulsky I, Shragge B, Teoh K, Lonn E, Sawchuk C, Oezaslan F. Left Atrial Appendage Occlusion Study (LAAOS): A randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention. Am Heart J. 2003 Jan;145(1):174-178  

Sheldon R, Rose S, Connolly SJ. Prevention of syncope trial (POST). A randomized trial of beta blockers in prevention of vasovagal syncope: Rationale and study design. Europace. 2003 Jan;5(1):71-5.  

Connolly SJ. Preventing stroke in patients with atrial fibrillation: Current treatments and new concepts. Am Heart J . 2003 Mar;145(3):418-23

Healey J, Connolly SJ. Atrial fibrillation: Hypertension as a causative agent, risk factor for complications and potential therapeutic target. Am J Cardiol 2003 May 22;91(10A):9G-14G  

Connolly SJ, Schnell DJ, Page RL, Wilkinson WE, Marcello SR, Pritchett EL for the Azimilide Supraventricular Arrhythmia Program Investigators. Symptoms At The Time Of Arrhythmia Recurrence In Patients Receiving Azimilide For Control Of Atrial Fibrillation Or Flutter: Results From Randomized Trials Am Heart J 2003; 146:489-93.  

Newman D, Lau C, Tang AS, Irvine J, Paquette M, Woodend K, Dorian P, Gent M, Kerr C, Connolly SJ. Effect of pacing mode on health-related quality of life in the Canadian Trial of Physiologic Pacing. Am HeartJ. 2003 Mar;145(3):430-7.

Hohnloser SH, Connolly SJ. Combined Antiplatelet Therapy in Atrial Fibrillation: J Cardiovasc Electrophysiol 2003 Sep;14 Suppl 9:S60-S63. 

Connolly SJ Prevention of Vascular Events in Patients with Atrial Fibrillation: J Cardiovasc Electrophysiol. 2003 Sep;14 Suppl 9:S52-S55.  

Crystal E, Healey J, Connolly SJ Atrial fibrillation after cardiac surgery: update on the evidence on the available prophylactic interventions. Card Electrophysiol Rev. 2003 Jun;7(2):189-92  

Yee R, Connolly SJ, Noorani H Clinical review of radiofrequency catheter ablation for cardiac arrhythmias. Can J Cardiol. 2003 Oct;19(11):1273-84

Gronefeld G, Connolly SJ, Hohnloser SH, The DINAMIT Investigators. The Defibrillator in Acute Myocardial Infarction Trial (DINAMIT): Rationale, Design and Specific Aims. Card Electrophysiol Rev 2003;7(4):447-51  

Crystal E, Healey J, Connolly SJ. Atrial fibrillation after cardiac surgery: update on the evidence on the available prophylactic interventions. Card Electrophysiol Rev. 2003 Jun;7(2):189-92

van Walraven C, Hart RG, Singer DE, Koudstaal PJ, Connolly SJ. Oral anticoagulants vs. aspirin for stroke prevention in patients with non-valvular atrial fibrillation: the verdict is in. Card Electrophysiol Rev. 2003 Dec;7(4):374-8  

Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2003 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes. 2003;27(suppl 2):S1-S152.

Hunt D, Gerstein H. Foot ulcers and amputations in diabetes. Clin Evid. 2003 Jun;(9):651-9.

Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin EndorinolMetab 2003;88(10):4551-4555.  

Mann JFE, Gerstein HC, Dulau-Florea I, Lonn E. Cardiovascular risk in patients with mild renal insufficiency. Kidney Intern 2003; 63 (suppl 84): S192 - S196.  

Gerstein HC. A disturbed glucose metabolic state (dysglycaemia): A key risk factor for cardiovascular events. Eur Heart J Supplements 2003; 5 (Supp B): B1-B2.  

Josse RG, Chiasson J-L, Ryan EA, Lau DCW, Ross SA, Yale J-F, Leiter LA, Maheux P, Tessier D, Wolever TMS, Gerstein H, Rodger NW, Dornan JM, Murphy L, Rabassa-Lhoret R, Meneilly G. Acarbose in the treatment of elderly patients with type 2 diabetes. Diabetes Research and ClinicalPractice 2003;59(1):37-42.

Anand SS. Oral anticoagulants in patients with coronary artery disease: an inexpensive and effective strategy. Thromb Res. 2003 Feb 15;109(4):159-61.  

Hackam D, Anand S. Emerging risk factors for atherosclerotic vascular disease. JAMA 2003 Aug 20;290(7):932-40.  

Anand S, Creager M. Peripheral arterial occlusive disease (PAVK). Vasa 2003 Aug;32(3):179-80.  

Warkentin T, Moore J, Anand S, Lonn E, Morgan D. Gastrointestinal Bleeding, Angiodysplasia, Cardiovascular Disease, and Acquired von Willebrand Syndrome. Transfus Med Rev 2003 Oct;17(4):272-286.  

Eikelboom, Anand S, Antiplatelet agents in Acute Coronary Syndrome. Semin Vasc Med 2003 Nov;3(4):403-14.  

Levy AR, O’Brien BJ, McMullen E, May FW, Demers C, Marshall D, MacLeod S. Rapid increase in statins newly dispensed to Ontario seniors between 1994 and 2000. Can J Cardiol 2003:19:665-669.  

Demers C, McKelvie RS. Growth hormone therapy in heart failure: where are we now? Congestive HeartFailure 2003:9:84-90.  

Theal M, Demers C, McKelvie RS. The role of angiotensin II receptor blockers in the treatment of heart failure patients. Congestive Heart Failure 2003;9:29-34.

Anderson TJ, Robertson AC, Hildebrand K, Conradson HE, Jones C, Bridge P, Edworthy S, Lonn E, Ruddy T, Verma S, Charbonneau F. The fate of endothelial function testing: Rationale and design of the Firefighters And Their Endothelium (FATE). Can J Cardiol 2003;19(1):61-66.  

Mathew J, Lonn E, Schweiger M, Sleight P. Regression of left ventricular hypertrophy and its effect on cardiovascular morbidity and mortality. Cardiovascular Reviews & Reports 2003;24:38-43.

Sudlow C, Lonn E, Pignone M, Ness A, Rihal C. Secondary prevention of ischaemic cardiac event. Clin Evid 2003;9:166-205.  

Natarajan M. Angina (unstable). Clin Evid 2003; Dec (10): 64-75.  

Bhandari M, Montori V, Devereaux PJ, Dosanjh S, Sprague S, Guyatt GH. Challenges to the practice of evidence-based medicine during residents' surgical training: a qualitative study using grounded theory. Acad Med . 2003 Nov;78(11):1183-90.  

Bhandari M, Devereaux PJ, Swiontkowski MF, Tornetta P 3rd, Obremskey W, Koval KJ, Nork S, Sprague S, Schemitsch EH, Guyatt GH. Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. A meta-analysis. J Bone Joint Surg Am . 2003 Sep;85-A(9):1673-81.

Bhandari M, Devereaux PJ, Swiontkowski MF, Schemitsch EH, Shankardass K, Sprague S, Guyatt GH. A randomized trial of opinion leader endorsement in a survey of orthopaedic surgeons: effect on primary response rates. Int J Epidemiol . 2003 Aug;32(4):634-6  

Bhandari M, Whang W, Kuo JC, Devereaux PJ, Sprague S, Tornetta P 3 rd. The risk of false-positive results in orthopaedic surgical trials. Clin Orthop . 2003 Aug;(413):63-9

Sprague S, Bhandari M, Devereaux PJ, Swiontkowski MF, Tornetta P 3rd, Cook DJ, Dirschl D, Schemitsch EH, Guyatt GH. Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am. 2003 Jan;85-A(1):158-63.  

Collins JF, Garg R, Teo KK, Williford WO, Howell CL; DIG Investigators. The role of the data coordinating center in the IRB review and approval process: the DIG trial experience. Control Clin Trials. 2003 Dec;24(6 Suppl):306S-315S.

Burton JR, Teo KK, Buller CE, Plante S, Catellier D, Tymchak W, Taylor D, Dzavik V, Montague TJ; SCAT investigators. Effects of long term cholesterol lowering on coronary atherosclerosis in patient risk factor subgroups: the Simvastatin/enalapril Coronary Atherosclerosis Trial (SCAT). Can J Cardiol. 2003 Apr;19(5):487-91.  

Bungard TJ, Ghali WA, McAlister FA, Buchan AM, Cave AJ, Hamilton PG, Mitchell LB, Shuaib A, Teo KK, Tsuyuki RT. The relative importance of barriers to the prescription of warfarin for nonvalvular atrial fibrillation. Can J Cardiol. 2003 Mar 15;19(3):280-4.  

Mehta SR. Aspirin and clopidogrel in patients with ACS undergoing PCI: CURE and PCI-CURE. J InvasiveCardiol. 2003 Mar;15 Suppl B:17B-20B; discussion 20B-21B.

Wittchen HU, Krause P, Hofler M, Pfister H, Ritz E, Goke B, Lehnert H, Tschope D, Kirch W, Pittrow D, Sharma AM, Bramlage P, Kupper B, Unger T. [Hypertension, diabetes mellitus and comorbidity in primary care] . Fortschr Med Orig. 2003 Feb 27;121 Suppl 1:19-27.  

Krause P, Wittchen HU, Kupper B, Pittrow D, Unger T, Sharma AM, Ritz E, Goke B, Lehnert H, Tschope D, Kirch W, Pfister H, Bramlage P, Hofler M. [Management of diabetes and hypertension: how do primary care physicians judge their performance?] Fortschr Med Orig. 2003 Feb 27;121 Suppl 1:12-8.

Wittchen HU, Krause P, Hofler M, Pfister H, Kupper B, Pittrow D, Bramlage P, Unger T, Sharma AM, Ritz E, Goke B, Lehnert H, Tschope D, Kirch W. [Aim, design and methods of the "Hypertension and diabetes screening and awareness" -- (HYDRA) study]. Fortschr Med Orig . 2003 Feb 27;121 Suppl 1:2-11.  

Boschmann M, Steiniger J, Hille U, Tank J, Adams F, Sharma AM, Klaus S, Luft FC, Jordan J. Water-induced thermogenesis. J Clin Endocrinol Metab. 2003 Dec;88(12):6015-9.  

Tank J, Jordan J, Diedrich A, Schroeder C, Furlan R, Sharma AM, Luft FC, Brabant G. Bound leptin and sympathetic outflow in nonobese men. J Clin Endocrinol Metab. 2003 Oct;88(10):4955-9.  

Sharma AM. Obesity and cardiovascular risk. Growth Horm IGF Res. 2003 Aug;13 Suppl A:S10-7.  

Buchholz K, Schachinger H, Wagner M, Sharma AM, Deter HC. Reduced vagal activity in salt-sensitive subjects during mental challenge . Am J Hypertens. 2003 Jul;16(7):531-6.

Tank J, Schroeder C, Diedrich A, Szczech E, Haertter S, Sharma AM, Luft FC, Jordan J. Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition. Circulation. 2003 Jun 17;107(23):2949-54.  

Wellner M, Herse F, Janke J, Gorzelniak K, Engeli S, Bechart D, Lasalle P, Luft FC, Sharma AM. Endothelial cell specific molecule-1--a newly identified protein in adipocytes. Horm Metab Res. 2003 Apr;35(4):217-21.  

Tank J, Schroeder C, Stoffels M, Diedrich A, Sharma AM, Luft FC, Jordan J. Pressor effect of water drinking in tetraplegic patients may be a spinal reflex. Hypertension. 2003 Jun;41(6):1234-9.

Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM. The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? Int J Biochem CellBiol. 2003 Jun;35(6):807-25

Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, Mohlig M, Pfeiffer AF, Luft FC, Sharma AM. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 2003 Apr;52(4):942-7

Haennel RG, Teo KK, Suthijumroon A, Senaratne MP, Hetherington M, Ryan E, Kappagoda CT Heart rate/stroke volume relationship during upright exercise in long-term diabetics Can J Appl Physiol. 1993 Jun;18(2):148-62

Haraphongse M, Na-Ayudhya RK, Williams R, Teo KK, Bay KS, Humen D, Gelfand E, Modry D, Callaghan JC, Montague T. Long term clinical outcomes following isolated mitral valve replacement . Can J Cardiol. 1993 Jun;9(5):417-22.

Peters H, Ruckert M, Gaedeke J, Liefeldt L, Ketteler M, Sharma AM, Neumayer HH. Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis. J Hypertens . 2003 Apr;21(4):771-80

Boschmann M, Jordan J, Adams F, Christensen NJ, Tank J, Franke G, Stoffels M, Sharma AM, Luft FC, Klaus S. Tissue-specific response to interstitial angiotensin II in humans . Hypertension. 2003 Jan;41(1):37-41.

Healey JS, Davies RF, Smith SJ, Davies RA, Ooi DS. The Prognostic Use of Cardiac Troponin T and Troponin I in Patients with Heart Failure. Can J Cardiol 2003; 19(4): 383-386.

Zenuk C, Healey J, Donnelly J, Vaillancourt R, Almalki Y, Smith S. Thiamine deficiency in congestive heart failure patients receiving long-term furosemide therapy. Can J Clin Pharmacol. 2003 Winter; 10(4): 184-188.